Water → HCID 69067984、化合物
反応式
[C:1]1([C:7]2[O:8][C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:10][C:11]=2[C:12]#N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH2:20].[OH-:21].[Na+]>C(O)CO>[C:1]1([C:7]2[O:8][C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:10][C:11]=2[C:12]([OH:21])=[O:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
5
実験手順
A suspension of 2,5-diphenylfuran-3-carbonitrile (0.87 g, 3.56 mmol) in ethylene glycol and 3M NaOH (10 ml) was heated at reflux for 3 days. Water was added to the reaction mixture and extracted into CH2Cl2. The organic layer was dried with MgSO4, filtered and concentrated to provide 2,5-diphenylfuran-3-carboxylic acid (intermediate XXVIf, 900 mg) as white solid.
後処理
- temperaturewas heated
- temperatureat reflux for 3 days
- extractionextracted into CH2Cl2
- dry with materialThe organic layer was dried with MgSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-f3213b59182c4e2b82865e4edc8b0ada
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07491821B2
反応ノート
読み込み中…