Pyridine → 1-Benzyl-3-methyl-piperidin-4-one oxime
反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.Cl.[NH2:23][OH:24]>CCO>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[N:23][OH:24])[CH:10]([CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 1-benzyl-3-methyl-piperidin-4-one (2.04 g, 10 mmol) in EtOH (20 mL), was added pyridine (20 mL, 0.25 mol) and hydroxylamine hydrochloride (0.70 g, 10 mmol). After being stirred at 90+ C. overnight, the resultant solution was concentrated in vacuo to give the crude product 1-benzyl-3-methyl-piperidin-4-one oxime. LC/MS m/z: 219 (M+H)+. This material was used without further purification.
後処理
- concentrationovernight, the resultant solution was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-a68331378fc047c19a9cff0ff75b5a09
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07491827B2
反応ノート
読み込み中…