Hydrochloric Acid → 3-(Dimethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-one hydrochloride
反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=1)=[O:3].[CH2:14]=O.[ClH:16].[CH3:17][NH:18][CH3:19].Cl>CCO>[ClH:16].[CH3:17][N:18]([CH3:14])[CH2:19][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[CH:5]=1)=[O:3]参加物
6
実験手順
3-(Trifluoromethyl) acetophenone (5.00 g, 26.6 mmol), paraformaldehyde (1.596 g, 2 eq.), dimethylamine hydrochloride (3.25 g, 1.5 eq.) were mixed together in 7 ml of EtOH, treated with 0.08 ml of 37% HCl, and heated to reflux for 5 h. Cooling down to ambient temperature, filtration and washing with tiny amounts of cold EtOH delivered 5.58 g of the title compound as white crystals of mp. 144-146° C. (dec.).
後処理
- temperatureheated
- temperatureto reflux for 5 h
- washwashing with tiny amounts of cold EtOH
出典と根拠
- ORDレコード
- ord-a2728724b3e244afbba07ecbd38399f9
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07495001B2
反応ノート
読み込み中…