1,1,1-Trifluorooctan-2-YL 2-fluoro-4-hydroxybenzoate → 4-(Octyloxy)benzoic acid

HRID 1728526ノート

反応式

HRID 1728526 の反応式
FC1C=C(O)C=CC=1C(OC(CCCCCC)C(F)(F)F)=O.C(OC1C=C[C:35]([C:38]2C=C[C:41]([C:44]([O:46][C:47]3[CH:52]=[CH:51][C:50]([C:53]([O:55]C(CCCCCC)C(F)(F)F)=[O:54])=[C:49](F)[CH:48]=3)=O)=[CH:40][CH:39]=2)=[CH:34][CH:33]=1)CCCCCCC>O1CCCC1>[CH2:44]([O:46][C:47]1[CH:48]=[CH:49][C:50]([C:53]([OH:55])=[O:54])=[CH:51][CH:52]=1)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:35][CH2:34][CH3:33]

参加物

4

反応物 2

HCID 199208191,1,1-Trifluorooctan-2-YL 2-fluoro-4-hydroxybenzoateHCID 537499373-Fluoro-4-(1,1,1-trifluoro-2-octyloxycarbonyl)phenyl 4-octyloxybiphenyl-4'-carboxylate

生成物 1

HCID 172314-(Octyloxy)benzoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the 1,1,1-trifluoro-2-decyl-6-hydroxynaphthalene-2-carboxylate (0.5 g) obtained in (1) above, the 4-n-octyloxybenzoic acid (0.4 g) obtained in (2) above in tetrahydrofuran (40 ml) were added dicyclohexylcarbodiimide (0.45 g) and dimethylaminopyridine (0.05 g). The solution was stirred at room temperature overnight. The solution was distilled to remove the solvent. The residue was dissolved in dichloromethane (50 ml) and the solution was washed with dilute aqueous hydrochloric acid solution and water in this order. The organic layer collected was dried over anhydrous magnesium sulfate, and distilled to remove the solvent. The residue was purified by silica-gel column chromatography (developer: hexane/ethyl acetate=20/1) to obtain the titled compound (0.39 g) having specific rotation, [α]DD20 =+45.79°.

出典と根拠

ORDレコード
ord-fdd2df0e504d4df08ae9aa70898a8166
出典データセット
uspto-grants-1994_07
特許番号
US05328641

反応ノート

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