Acetic Acid → 2-(5-methyl-1,3,4-oxadiazol-2-yl)aniline
反応式
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)O[C:2]2=O.C1(C)C=CC(S(O)(=O)=O)=CC=1.C(O)(=O)C.[C:28]([NH:31][NH2:32])(=[O:30])[CH3:29]>C1(C)C=CC=CC=1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]1[O:30][C:28]([CH3:29])=[N:31][N:32]=1参加物
6
反応条件
- 温度
- 120 °C
実験手順
A mixture of isatoic anhydride (16.3 g, 0.1 mol), p-toluenesulfonic acid (0.2 g, 1.1 mmol), glacial acetic acid (10 ml), acethydrazide (7.4 g, 0.1 mol) and dry toluene (90 ml) was stirred at 120° C. for 4 h, cooledto room temperature and poured into ice water. Toluene (500 ml) was added, and the phases were separated. The aqueous phase was extracted with CH2Cl2 (2×100 ml).
後処理
- customcooledto room temperature
- customthe phases were separated
- extractionThe aqueous phase was extracted with CH2Cl2 (2×100 ml)
出典と根拠
- ORDレコード
- ord-ffb816bf758d4ab3ae9d28fc55f06bf4
- 出典データセット
- uspto-grants-1994_07
- 特許番号
- US05330990
反応ノート
読み込み中…