Ammonia → 4-Nitroaniline

HRID 1729117

反応式

HRID 1729117 の反応式
N.[N+:2]([C:5]1[CH:19]=[CH:18][C:8]([NH:9]C(=O)C2C=CC=CC=2)=[CH:7][CH:6]=1)([O-:4])=[O:3].C(N)(=O)C1C=CC=CC=1>CO>[N+:2]([C:5]1[CH:19]=[CH:18][C:8]([NH2:9])=[CH:7][CH:6]=1)([O-:4])=[O:3]

参加物

5

反応物 3

HCID 222AmmoniaHCID 2331BenzamideHCID 769304'-Nitrobenzanilide

生成物 1

HCID 74754-Nitroaniline収率 50%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
120 °C

実験手順

Approximately 10 ml of liquid ammonia was added rapidly to a solution of 100 mg of 4'-nitrobenzanilide and 50 ml of methanol in a Parr bomb at -50° C. The Parr reactor was stirred at 120° C./300 psi (21.1 kg/cm2) for 3 days. After the reactor was cooled to -50°C., the pressure was released and the reactor was opened. An aliquot was taken out for HPLC analysis which revealed a 50% yield of 4-nitroaniline and benzamide. The remainder of the material was unreacted.

後処理

  1. temperatureAfter the reactor was cooled to -50°C.

出典と根拠

ORDレコード
ord-c9dcf08f15d24adda6480693506c057c
出典データセット
uspto-grants-1994_07
特許番号
US05331099

関連ノート

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