Sodium Hydroxide → Ethnor

HRID 1730047

反応式

HRID 1730047 の反応式
S(O)(O)(=O)=O.[C:6]1([CH:12]([N:14]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][N:16]=[CH:15]2)[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[Na+]>O>[C:6]1([CH:12]([N:14]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][N:16]=[CH:15]2)[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 3084993Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate

生成物 1

HCID 36339Ethnor

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 47.5 parts of (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate in 500 parts of water is alkalized with 14 parts of a sodium hydroxide solution 50%. The product is extracted twice with 325 parts of dichloromethane. The combined extracts are dried, filtered and evaporated in vacuo. The residue is crystallized from 2,2'-oxybispropane, yielding (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate.

後処理

  1. extractionThe product is extracted twice with 325 parts of dichloromethane
  2. customThe combined extracts are dried
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe residue is crystallized from 2,2'-oxybispropane

出典と根拠

ORDレコード
ord-5bdca24f7ac64c88b979240b23bff893
出典データセット
uspto-grants-1976_11
特許番号
US03991072

関連ノート

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