N1C=CC=CC=1.[CH3:7][C:8]([CH3:27])([CH3:26])[C:9]([NH:11][C:12]1[C:20]([O:21][CH3:22])=[C:19]([F:23])[C:18]([I:24])=[C:17]([CH3:25])[C:13]=1[C:14]([NH2:16])=O)=[O:10].FC(F)(F)S(OS(C(F)(F)F)(=O)=O)(=O)=O>CN(C)C1C=CN=CC=1.C(OCC)(=O)C>[C:14]([C:13]1[C:17]([CH3:25])=[C:18]([I:24])[C:19]([F:23])=[C:20]([O:21][CH3:22])[C:12]=1[NH:11][C:9](=[O:10])[C:8]([CH3:26])([CH3:7])[CH3:27])#[N:16]4-Dimethylaminopyridine (149 mg, 1.22 mmol) was added to a pyridine (100 ml) suspension of 2-(2,2-dimethylpropionylamino)-4-fluoro-5-iodo-3-methoxy-6-methylbenzamide (I-68) (4.97 g, 1.22 mmol), and cooled at 0° C. Trifluoromethanesulfonic acid anhydride (6.17 ml, 36.5 mmol) was dropwise added to it, followed by stirring at room temperature for 1 hour, then ethyl acetate (400 ml) was put thereinto. The organic layer was washed with 1 N hydrochloric acid (300 ml×5), saturated brine (300 ml×2), then dried over anhydrous magnesium sulfate, concentrated under reduced pressure, the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1) to obtain the entitled compound (4.47 g, 94%) as a pale yellow solid.
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