Sodium Hydroxide → N,N-Dimethylaminopropyl acrylamide

HRID 1732230

反応式

HRID 1732230 の反応式
[CH3:1][N:2]([CH3:13])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:12])[CH2:8][CH2:9]OC.[OH-].[Na+]>>[CH3:13][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:12])[CH:8]=[CH2:9]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 3097421N-(3-dimethylaminopropyl)-3-methoxypropionamide

生成物 1

HCID 77452N,N-Dimethylaminopropyl acrylamide

実験手順

188.3 g (1.0 mole) of N-(3-dimethylaminopropyl)-3-methoxypropionamide (according to Example 13 ) are heated with 1.5 g of sodium hydroxide at 90°-110° C. in a high vacuum. Within about 30 minutes methanol is split off, vigorous forming occurring. The temperature is increased and 103 g (0.66 mole=66% of the theoretical yield) of colorless oil having a Bp0.1 of 96°-100° C. are distilled off.

後処理

  1. customWithin about 30 minutes methanol is split off
  2. customvigorous forming
  3. temperatureThe temperature is increased
  4. custom103 g (0.66 mole=66% of the theoretical yield) of colorless oil
  5. customa Bp0.1 of 96°-100° C.
  6. distillationare distilled off

出典と根拠

ORDレコード
ord-69b2edd453b647a8857b466efd7201f5
出典データセット
uspto-grants-1980_12
特許番号
US04237067

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