Ethyl Bromide → N-Ethyl-N-methyl-2-thiophene methanamine

HRID 1732894

反応式

HRID 1732894 の反応式
BrCC.[CH2:4]([N:6]([CH2:9][CH3:10])[CH2:7][CH3:8])C.CNC[C:14]1[S:15]C=[CH:17][CH:18]=1>C1(C)C=CC=CC=1.O.C(=O)(O)[O-].[Na+]>[CH2:7]([N:6]([CH3:4])[CH2:9][C:10]1[S:15][CH:14]=[CH:18][CH:17]=1)[CH3:8]

参加物

7

反応物 3

HCID 6332Ethyl BromideHCID 8471TriethylamineHCID 436153N-Methyl-1-(thiophen-2-yl)methanamine

生成物 1

HCID 12788071N-Ethyl-N-methyl-2-thiophene methanamine

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 1140Toluene溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

Bromoethane (150 ml), triethylamine (7.3 ml) and N-methyl-2-thiophenemethanamine (21.2 g) were stirred at room temperature in toluene (212 ml) for 4 days. The solution was diluted with water, saturated with sodium bicarbonate and extracted with ethyl acetate. The organic extracts were distilled to give the title compound as an oil (13.6 g) b.p. 46° (16 mm).

後処理

  1. extractionextracted with ethyl acetate
  2. distillationThe organic extracts were distilled

出典と根拠

ORDレコード
ord-2cc545f257c747f1846a3e4260f3340f
出典データセット
uspto-grants-1980_12
特許番号
US04239769

関連ノート

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