Hydrochloric Acid → 2-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide

HRID 1733147

反応式

HRID 1733147 の反応式
[NH2:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8].[Cl:11][CH2:12][C:13](Cl)=[O:14].Cl>C1(C)C=CC=CC=1>[Cl:11][CH2:12][C:13]([NH:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8])=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 2902202-Amino-4,5-dimethyl-3-furancarbonitrile

生成物 1

HCID 162273542-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide収率 122.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

20.4 g (0.1 mole) of 2-amino-3-cyano-4,5-dimethylfurane and 17.5 g (0.155 mole) of chloroacetyl chloride were boiled in 200 ml of toluene until the evolution of hydrogen chloride had subsided. Thereafter, the solvent was evaporated off under reduced pressure and the residue was recrystallized from ethyl acetate. 26 g of 2-chloroacetylamino-3-cyano-4,5-dimethylfurane of melting point 114° C. were obtained in this manner.

後処理

  1. customThereafter, the solvent was evaporated off under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-732f528106744e908873ac48e9d38c0e
出典データセット
uspto-grants-1980_12
特許番号
US04240820

関連ノート

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