Ethanolamine → 3-n-Butyl-5-(2,4,5-trimethoxybenzylidene) hydantoin

反応式

[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:4]=1[CH:5]=O.[CH2:15]([N:19]1[C:23](=[O:24])[CH2:22][NH:21][C:20]1=[O:25])[CH2:16][CH2:17][CH3:18].C(CN)O>O.C(O)C>[CH2:15]([N:19]1[C:23](=[O:24])[C:22](=[CH:5][C:4]2[CH:7]=[C:8]([O:13][CH3:14])[C:9]([O:11][CH3:12])=[CH:10][C:3]=2[O:2][CH3:1])[NH:21][C:20]1=[O:25])[CH2:16][CH2:17][CH3:18]

参加物

実験手順

A mixture of 2,4,5-trimethoxybenzaldehyde (9.8 g; 0.05 mole), 3-n-butylhydantoin (7.8 g: 0.05 mole) and ethanolamine (4.6 g; 0.075 mole) in water/ethanol (50 ml/30 ml) was stirred and boiled under reflux for 3 hours. The cloudy solution was cooled in the refrigerator and the resultant yellow solid filtered off, washed with water, sucked dry and recrystallised from ethanol to give the title compound (14.5 g; 87%) m.p. 170° C.