2,4,6-Trimethoxybenzonitrile → N-HYDROXY-2,4,6-TRIMETHOXY-BENZAMIDINE

HRID 1734572ノート

反応式

HRID 1734572 の反応式
Cl.[NH2:2][OH:3].CC[O-].[Na+].[Na].[CH3:9][O:10][C:11]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([O:21][CH3:22])[C:12]=1[C:13]#[N:14]>C(O)C>[CH3:22][O:21][C:15]1[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=[C:11]([O:10][CH3:9])[C:12]=1[C:13](=[N:2][OH:3])[NH2:14]

参加物

6

反応物 4

HCID 757312,4,6-TrimethoxybenzonitrileHCID 443297Hydroxyamine hydrochlorideHCID 2723922Sodium ethoxideHCID 5360545Sodium

生成物 1

HCID 5191888N-HYDROXY-2,4,6-TRIMETHOXY-BENZAMIDINE

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a suspension of 13.8 g of hydroxylamine hydrochloride in 100 ml of ethanol is added, at a temperature in the region of 15° C., a solution of NaOC2H5 prepared by dissolving 4.3 g of sodium in 100 ml of ethanol. 12 g of 2,4,6-trimethoxybenzonitrile are introduced into the medium, followed by heating at reflux for 41 h before evaporating to dryness. The crystals are washed with water and with dichloromethane.

後処理

  1. additionis added, at a temperature in the region of 15° C.
  2. temperatureby heating
  3. temperatureat reflux for 41 h
  4. custombefore evaporating to dryness
  5. washThe crystals are washed with water and with dichloromethane

出典と根拠

ORDレコード
ord-6d38f2833779447cbd4d3dbb4de43b23
出典データセット
uspto-grants-1996_07
特許番号
US05534530

反応ノート

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