Nitric Acid → HCID 19436799、化合物

HRID 1735010ノート

反応式

HRID 1735010 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[N:14]([CH3:15])[N:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=[N:7][CH:8]=1.[N+:20]([O-])([OH:22])=[O:21].S(=O)(=O)(O)O.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[N:14]([CH3:15])[N:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[C:11]=2[N+:20]([O-:22])=[O:21])[N:6]=[N:7][CH:8]=1

参加物

5

反応物 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 19436789HCID 19436789、化合物

生成物 1

HCID 19436799HCID 19436799、化合物収率 99%

実験手順

5-Methoxy-3-[[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (Compound No. 5, 1.2 g, 0.0043 mole) was added to a mixture of nitric acid (5 mL) and sulfuric acid (13 mL), and the mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into ice and neutralized with 10% sodium hydroxide. Filtration gave, after drying, 5-methoxy-3-[[1-methyl-4-nitro-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (1.36 g, 99% yield) as a beige solid.

後処理

  1. filtrationFiltration
  2. customgave
  3. customafter drying

出典と根拠

ORDレコード
ord-7cf123965f1442e6a758d15a1866a81c
出典データセット
uspto-grants-1996_07
特許番号
US05536701

反応ノート

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