Thionyl Chloride → HCID 22625098、化合物
反応式
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1>ClC(Cl)Cl>[ClH:3].[Cl:3][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1参加物
4
反応条件
- 温度
- 5 °C
実験手順
Thionyl chloride (2.2 ml, 30 mmol) was added slowly to a solution of 4-(3-hydroxypropoxy)pyridine (3.1 g, 20 mmol) in trichloromethane (40 ml) at 5° C. The mixture was stirred at 5° C. for 1 hour and then at ambient temperature for 2 hours. The volatiles were removed by evaporation, the residue azeotroped with toluene and dried under vacuum to give 4-(3-chloropropoxy)pyridine hydrochloride (3.81 g, 91%) as a solid.
後処理
- waitat ambient temperature for 2 hours
- customThe volatiles were removed by evaporation
- customthe residue azeotroped with toluene
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-718a4e52de8f4ed193828b730b8c2ca2
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05962458
反応ノート
読み込み中…