Hydrochloric Acid → HCID 54500756、化合物

HRID 1740493ノート

反応式

HRID 1740493 の反応式
[F:1][C:2]([F:15])([F:14])[S:3]([O:6]S(C(F)(F)F)(=O)=O)(=[O:5])=[O:4].[CH3:16][O:17][CH2:18][C@@H:19]1[O:23][C:22](=[O:24])[N:21]([C:25]2[C:29]3[CH:30]=[CH:31][C:32](O)=[CH:33][C:28]=3[O:27][CH:26]=2)[CH2:20]1.Cl>N1C=CC=CC=1>[F:1][C:2]([F:15])([F:14])[S:3]([O:6][C:32]1[CH:31]=[CH:30][C:29]2[C:25]([N:21]3[CH2:20][C@H:19]([CH2:18][O:17][CH3:16])[O:23][C:22]3=[O:24])=[CH:26][O:27][C:28]=2[CH:33]=1)(=[O:5])=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 67749Trifluoromethanesulfonic anhydrideHCID 15381150HCID 15381150、化合物

生成物 1

HCID 54500756HCID 54500756、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5.8 ml (0.035 mol) of trifluoromethanesulphonic anhydride are added slowly to a solution, maintained at -20° C., of 7.6 g (0.029 mol) of (R)-5-(methoxymethyl)-3-(6-hydroxybenzofuran-3-yl)oxazolidin-2-one in 60 ml of pyridine. After returning to room temperature, the mixture is poured into ice and is brought to a pH of 6 by means of 2N hydrochloric acid. The product is then extracted with ethyl acetate, the solvent is evaporated under reduced pressure and the product is purified by chromatography on silica gel with a 10/90 mixture of cyclohexane and dichloromethane.

後処理

  1. customAfter returning to room temperature
  2. additionthe mixture is poured into ice
  3. extractionThe product is then extracted with ethyl acetate
  4. customthe solvent is evaporated under reduced pressure
  5. customthe product is purified by chromatography on silica gel with a 10/90 mixture of cyclohexane and dichloromethane

出典と根拠

ORDレコード
ord-0449bb5862384ee4875dbae51f03aa08
出典データセット
uspto-grants-1999_10
特許番号
US05969146

反応ノート

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