[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].[CH3:22][O:23][CH2:24]Cl.C(N(C(C)C)CC)(C)C>ClCCl.C(Cl)(Cl)Cl>[CH3:22][O:23][CH2:24][O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]To a solution of 5.44 g of ethyl 16-hydroxyhexadecanoate in 80 ml of dichloromethane was added under ice-cooling 1.63 ml of methoxymethyl chloride, 4.1 ml of diisopropylethylamine was added dropwise and then the mixture was stirred overnight. The reaction solution was diluted with chloroform, washed with water, dried over anhydrous sodium sulfate and distilled under reduced pressure. The residue was chromatographed over a silica gel column to afford the title compound as a colorless oily substance.
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