Formaldehyde → HCID 21834627、化合物

HRID 1741473ノート

反応式

HRID 1741473 の反応式
[CH2:1]([NH:8][CH2:9][CH2:10][CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C=O.[C:26]([BH3-])#N.[Na+]>CC#N.O>[CH2:1]([N:8]([CH2:9][CH2:10][CH:11]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:26])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 8032053HCID 8032053、化合物

生成物 1

HCID 21834627HCID 21834627、化合物

試薬・触媒・溶媒 1

HCID 18373917Acetonitrile--water (1/1)溶媒

実験手順

To a solution of N-benzyl-3,3-diphenylpropylamine (1.29 g, 4.30 mmol) and 30% aq. formaldehyde (1.50 ml, 20 mmol) in CH3CN:H2O (2:1, v/v, 40 ml) was added sodium cyanoborohydride (563 mg, 8.96 mmol) at 0° C. The reaction was allowed to warm to room temperature and stirred for 90 min. The organic solvent was evaporated, and the residue diluted with water and extracted with CH2Cl2. The organic extracts were washed with brine, dried (Na2SO4) and the solvent evaporated in vacuo to afford the title compound as an oil.

後処理

  1. customThe organic solvent was evaporated
  2. additionthe residue diluted with water
  3. extractionextracted with CH2Cl2
  4. washThe organic extracts were washed with brine
  5. dry with materialdried (Na2SO4)
  6. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-f68a81e662ee4b109caab7ff4a1b3354
出典データセット
uspto-grants-1999_10
特許番号
US05972984

反応ノート

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