2-Fluoroethyl bromide → 2-(4-Chlorobenzyl)-2-(2-fluoroethyl)malononitrile

HRID 1743555

反応式

HRID 1743555 の反応式
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]([C:10]#[N:11])[C:8]#[N:9])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:17][CH2:18][F:19]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]([CH2:17][CH2:18][F:19])([C:8]#[N:9])[C:10]#[N:11])=[CH:12][CH:13]=1

参加物

5

反応物 3

HCID 129822-Fluoroethyl bromideHCID 180822-((4-Chlorophenyl)methyl)propanedinitrileHCID 24758Sodium hydride

生成物 1

HCID 222350832-(4-Chlorobenzyl)-2-(2-fluoroethyl)malononitrile収率 24.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Using 1.00 g of (4-chlorobenzyl)malononitrile, 10 ml of N,N-di-methylformamide, 0.21 g of sodium hydride (60% in oil), and 0.67 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.30 g of 2-(4-chlorobenzyl)-2-(2-fluoroethyl)malononitrile (the present compound (24)).

出典と根拠

ORDレコード
ord-4d5cb6f0d1f6400e874a20bd787e4215
出典データセット
uspto-grants-2006_03
特許番号
US07011838B2

関連ノート

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