2-Nitropropane → 4-Methyl-4-nitrovaleronitrile

HRID 1744011ノート

反応式

HRID 1744011 の反応式
[C:1](#[N:4])[CH:2]=[CH2:3].[N+:5]([CH:8]([CH3:10])[CH3:9])([O-:7])=[O:6].[OH-].[Na+]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC>[CH3:9][C:8]([N+:5]([O-:7])=[O:6])([CH3:10])[CH2:3][CH2:2][C:1]#[N:4]

参加物

5

反応物 3

HCID 3982-NitropropaneHCID 7855AcrylonitrileHCID 14798Sodium Hydroxide

生成物 1

HCID 38791404-Methyl-4-nitrovaleronitrile

試薬・触媒・溶媒 1

HCID 8154Hexadecyltrimethylammonium chloride触媒

実験手順

(vii-1) Acrylonitrile and 2-nitropropane are reacted in the presence of hexadecyltrimethyl ammonium chloride in an aqueous alkali solvent such as aqueous sodium hydroxide solution and the like. Then, the reaction mixture is extracted to give 4-methyl-4-nitrovaleronitrile (European Journal of Organic Chemistry (1998), (2), 355–357). The obtained 4-methyl-4-nitrovaleronitrile can be isolated and/or purified by a conventional method, such as crystallization, chromatography and the like, but generally, can be used in the next step without isolation and/or purification.

後処理

  1. extractionThen, the reaction mixture is extracted

出典と根拠

ORDレコード
ord-07d62603c1ef42939130f0e4eab6b31b
出典データセット
uspto-grants-2006_03
特許番号
US07012152B2

反応ノート

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