Sodium Hydroxide → HCID 178510736、化合物
反応式
[OH-:1].[Na+].Cl.[NH2:4]O.[C:6]1([C:12]2([CH2:17][C:18]#[N:19])[O:16][CH2:15][CH2:14][O:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[OH:1][NH:19][C:18](=[NH:4])[CH2:17][C:12]1([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[O:16][CH2:15][CH2:14][O:13]1参加物
5
実験手順
Sodium hydroxide (3.1 g, 77 mmol) is added to hydroxylamine hydrochloride (5.2 g, 75 mmol) at 0° C. and is stirred for 15 min. A solution of (2-phenyl-1,3-dioxolan-2-yl)acetonitrile (7 g, 37 mmol) in methanol (25 mL) is added dropwise to the reaction mixture at 0° C. The reaction mixture is allowed to warm to room temperature and is heated at 90° C. for 16 h. The solvent was evaporated under reduced pressure to afford the title compound as a brown solid (7 g, 85%) which is used in the next step without purification.
後処理
- temperatureis heated at 90° C. for 16 h
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-dd78f62eaa754636b2b725d4d7c29e9e
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150577B2
反応ノート
読み込み中…