Chloroform → (3-Bromo-5-trifluoromethylsulfanylpyridine-2-yl)-methylamine

HRID 1750052ノート

反応式

HRID 1750052 の反応式
[Br:1]N1C(=O)CCC1=O.[CH3:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([S:17][C:18]([F:21])([F:20])[F:19])=[CH:13][N:12]=1.C(Cl)(Cl)Cl>O>[Br:1][C:16]1[C:11]([NH:10][CH3:9])=[N:12][CH:13]=[C:14]([S:17][C:18]([F:19])([F:21])[F:20])[CH:15]=1

参加物

5

反応物 3

HCID 6212ChloroformHCID 67184N-bromobutanimideHCID 67982149N-Methyl-5-((trifluoromethyl)thio)pyridin-2-amine

生成物 1

HCID 67981267(3-Bromo-5-trifluoromethylsulfanylpyridine-2-yl)-methylamine収率 93.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.43 g of N-bromosuccinimide was added to a mixture of 1.52 g of methyl-(5-trifluoromethylsulfanylpyridin-2-yl)-amine and 24 ml of chloroform, and the mixture was stirred at room temperature for 1 hour. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The combined organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 1.96 g of (3-bromo-5-trifluoromethylsulfanylpyridin-2-yl)-methylamine.

後処理

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-1c018e04ea034546a5b707024be217be
出典データセット
uspto-grants-2015_10
特許番号
US09156838B2

反応ノート

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