Hydrochloric Acid → 3-Cyclopropylpicolinic acid

HRID 1750486ノート

反応式

HRID 1750486 の反応式
[CH:1]1([C:4]2[C:5]([C:10]([O:12]C)=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:3][CH2:2]1.[OH-].[Li+].Cl>C1COCC1.O>[CH:1]1([C:4]2[C:5]([C:10]([OH:12])=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:2][CH2:3]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68687300Methyl 3-cyclopropylpyridine-2-carboxylate

生成物 1

HCID 686851453-Cyclopropylpicolinic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 3-cyclopropylpyridine-2-carboxylate (80 mg, 0.45 mmol) in THF (2 ml) and water (2 ml) was added lithium hydroxide (55 mg, 1.36 mmol) and the reaction mixture was refluxed for 2 hours. The reaction was then acidified to pH 2 using 1M HCl (aq) and extracted with DCM (3×50 ml). The combined organics were washed with water (30 ml), brine (30 ml), dried over sodium sulfate and concentrated in vacuo to afford the title compound.

後処理

  1. temperaturethe reaction mixture was refluxed for 2 hours
  2. extractionextracted with DCM (3×50 ml)
  3. washThe combined organics were washed with water (30 ml), brine (30 ml)
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-802bb63e6c1745ac80524b9fa1ec178f
出典データセット
uspto-grants-2015_10
特許番号
US09156829B2

反応ノート

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