2-Bromobenzyl bromide → Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate

HRID 1750729ノート

反応式

HRID 1750729 の反応式
[N:1]1([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:18][C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH2:21]Br.C(N(C(C)C)CC)(C)C>C(#N)C>[Br:18][C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH2:21][N:4]1[CH2:3][CH2:2][N:1]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][CH:17]=2)[CH2:6][CH2:5]1

参加物

5

反応物 3

HCID 769652-Bromobenzyl bromideHCID 81531DiisopropylethylamineHCID 2761178Ethyl 4-(piperazin-1-yl)benzoate

生成物 1

HCID 16109102Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of Example 4A (23.43 g, 100.0 mmol), 2-bromobenzyl bromide (26.24 g, 105.0 mmol) and diisopropylethylamine (20.94 mL, 120.0 mmol) in acetonitrile (200 mL) was stirred at room temperature for two hours. The resulting precipitate was collected by filtration to give the desired product, which was used without further purification.

後処理

  1. filtrationThe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-c6ca4aa9caf348d09eed9f7b90a67c24
出典データセット
uspto-grants-2015_10
特許番号
US09156856B2

反応ノート

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