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Potassium Permanganate → 1-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-1H-imidazole

HRID 1750901
ノート
印刷プレビュー

反応式

HRID 1750901 の反応式
[CH:1]([C:4]1[C:16]([N:17]2[CH2:21][CH2:20][N:19]=[C:18]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([CH:28]([CH3:30])[CH3:29])[C:7]2[O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[CH:5]=1)([CH3:3])[CH3:2].[Mn]([O-])(=O)(=O)=O.[K+]>C(#N)C.ClCCl>[CH:1]([C:4]1[C:16]([N:17]2[CH:21]=[CH:20][N:19]=[C:18]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([CH:28]([CH3:30])[CH3:29])[C:7]2[O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[CH:5]=1)([CH3:3])[CH3:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 516875Potassium PermanganateHCID 584008541-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-4,5-dihydro-1H-imidazole

生成物 1

HCID 584008691-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-1H-imidazole収率 72%

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 6344Dichloromethane溶媒

実験手順

1-(2,4-diisopropyldibenzo[b,d]furan-3-yl)-2-phenyl-4,5-dihydro-1H-imidazole (7.4 g, 18.66 mmol) was dissolved in 200 mL of acetonitrile and 100 mL of dichloromethane. Potassium Permanganate (5.90 g, 37.3 mmol) and Clay K10 (12 g, 30.7 mmol) were ground in a mortar. The solid was then added carefully to the solution. Heat was generated after a few minutes. The reaction was monitored by TLC. The reaction was quenched with methanol after 1.5 h. The reaction mixture was filtered through Celite. The solvent was evaporated and the residue was purified by column. 5.3 g (72% yield) of pure product was obtained.

後処理

  1. additionThe solid was then added carefully to the solution
  2. temperatureHeat
  3. waitwas generated after a few minutes
  4. customThe reaction was quenched with methanol after 1.5 h
  5. filtrationThe reaction mixture was filtered through Celite
  6. customThe solvent was evaporated
  7. customthe residue was purified by column

出典と根拠

ORDレコード
ord-d640ad05ac1942e29ea79d3538c0a3a5
出典データセット
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09156870B2

反応ノート

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