Hydrochloric Acid → 3-Amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid

HRID 1752504ノート

反応式

HRID 1752504 の反応式
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([CH2:12][CH2:13][O:14][CH3:15])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+].Cl>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([CH2:12][CH2:13][O:14][CH3:15])[N:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 712711513-Amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid methyl ester

生成物 1

HCID 866891713-Amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid methyl ester (147 mg, 0.696 mmol) in THF (14 ml) was added 1M NaOH (1.74 ml, 1.74 mmol) and the reaction mixture was stirred at room temperature for 2 h. 1M HCl (1.601 ml, 1.601 mmol) was added to the reaction mixture. The resulting mixture was evaporated and co-evaporated with toluene. The resulting crude material was directly used in the coupling step without further purification.

後処理

  1. customThe resulting mixture was evaporated
  2. customThe resulting crude material was directly used in the coupling step without further purification

出典と根拠

ORDレコード
ord-34bc511b2fed4638b82eb139e05c4c6b
出典データセット
uspto-grants-2015_10
特許番号
US09163011B2

反応ノート

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