Hydrochloric Acid → 1-(2-Methylphenyl)-1H-1,2,4-triazole-3-carboxylic acid
反応式
[C:1]1([CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH:11]=[N:10][C:9]([C:12]([O:14]CC)=[O:13])=[N:8]1.[Li+].[OH-].CO.Cl>C1COCC1>[C:1]1([CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH:11]=[N:10][C:9]([C:12]([OH:14])=[O:13])=[N:8]1参加物
6
反応条件
- 温度
- 50 °C
実験手順
To a solution of ethyl 1-(o-tolyl)-1,2,4-triazole-3-carboxylate (400 mg, 1.7 mmol) in 3 mL THF was added 4 M LiOH (2 mL, 8 mmol) followed by 3 mL of MeOH. The reaction mixture was stirred at 50° C. for 5 minutes, after which the pH was adjusted to 4 with the addition of conc. HCl. After extraction, drying (MgSO4), filtration and drying under reduced pressure, 43 mg of residue was recovered (12%) and used in the subsequent step without further purification.
後処理
- extractionAfter extraction
- customdrying
- filtration(MgSO4), filtration
- dry with materialdrying under reduced pressure, 43 mg of residue
- customwas recovered (12%)
- customused in the subsequent step without further purification
出典と根拠
- ORDレコード
- ord-17a51cb946f349c5b0cc40a8e4901319
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09169261B2
反応ノート
読み込み中…