Methanol → HCID 15712257、化合物

HRID 1756436ノート

反応式

HRID 1756436 の反応式
[C:1]([C:4]1[CH:15]=[CH:14][C:7]([C:8]([O:10][CH2:11][CH:12]=[CH2:13])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].CO.C1COCC1.[BH4-].[Na+]>O>[OH:3][CH:1]([C:4]1[CH:15]=[CH:14][C:7]([C:8]([O:10][CH2:11][CH:12]=[CH2:13])=[O:9])=[CH:6][CH:5]=1)[CH3:2]

参加物

6

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 21474599HCID 21474599、化合物

生成物 1

HCID 15712257HCID 15712257、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3.1 g (15 mmol) of the allyl ester obtained above in (a), 20 ml of methyl alcohol and 20 ml of THF are introduced into a round-bottomed flask. While cooling in an icebath, 285 mg (7.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for one hour. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, then dried over magnesium sulphate and evaporated. 3.1 g (100% ) of the expected product are collected in the form of a colorless oil.

後処理

  1. additionare introduced into a round-bottomed flask
  2. additionare added in small portions
  3. extractionthe mixture is extracted with ethyl ether
  4. customthe organic phase is separated after settling
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. custom3.1 g (100% ) of the expected product are collected in the form of a colorless oil

出典と根拠

ORDレコード
ord-a9d74e80d8524f76b773f86e6bc69406
出典データセット
uspto-grants-1995_08
特許番号
US05439925

反応ノート

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