Water → 6-Nitroquinoline-2-carboxylic acid

HRID 1756505ノート

反応式

HRID 1756505 の反応式
[CH:1](=[C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:18]([O-:20])=[O:19])[CH:14]=2)[NH:9]1)C1C=CC=CC=1.[O-:21][Mn](=O)(=O)=O.[K+].[OH2:27]>N1C=CC=CC=1>[C:1]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:18]([O-:20])=[O:19])[CH:14]=2)[N:9]=1)([OH:21])=[O:27]

参加物

5

反応物 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 67619679HCID 67619679、化合物

生成物 1

HCID 123242586-Nitroquinoline-2-carboxylic acid収率 39%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 2-benzylidene-6-nitroquinoline (4.9 g; 17.7 mM) in pyridine (36.6 ml) and water (8 ml) was added portion wise KMnO4 (7.5 g; 47.8 mM) keeping the temperature between 18 and 20° C. After filtration on celite, the solution was acidified (pH3), at 0° C., with H2SO4 (65%). The resulting precipitate was filtered, washed with water and ether and then dried to give 2-carboxy-6-nitroquinoline (1.5 g; 39%).

後処理

  1. customthe temperature between 18 and 20° C
  2. filtrationAfter filtration on celite
  3. customat 0° C.
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with water and ether
  6. customdried

出典と根拠

ORDレコード
ord-7aa3c28a5ebf48368cae92f6cd761c7f
出典データセット
uspto-grants-1995_08
特許番号
US05441949

反応ノート

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