Thionyl Chloride → HCID 19973449、化合物

HRID 1757114ノート

反応式

HRID 1757114 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434、化合物

生成物 1

HCID 19973449HCID 19973449、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

6.80 g of the 2-methylimidazo[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2-methylimidazo[1,2-a]pyridine hydrochloride was obtained as a brown oil.

後処理

  1. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-26de46e450de4893b074045faa784f42
出典データセット
uspto-grants-1995_08
特許番号
US05444066

反応ノート

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