Methyl iodide → HCID 19390114、化合物
反応式
[F:1][C:2]1[C:3]([OH:13])=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][N:6]([CH3:8])[CH3:7].[CH3:14][I:15]>C(Cl)(Cl)Cl>[I-:15].[F:1][C:2]1[C:3]([OH:13])=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][N+:6]([CH3:14])([CH3:8])[CH3:7]参加物
4
実験手順
74 g (0.40 mol) of 3,5-difluoro-2-hydroxy-N,N-dimethylbenzylamine was dissolved in 300 ml of chloroform, and 200 ml of methyl iodide was added thereto. The mixture was heated under reflux for 3 hr to deposit a yellow precipitate. The precipitate was recovered by filtration to prepare 114 g (yield: 87%) of the intended product.
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 3 hr
- filtrationThe precipitate was recovered by filtration
出典と根拠
- ORDレコード
- ord-930c03ff64fb4ccd92b94561a23781ae
- 出典データセット
- uspto-grants-1995_08
- 特許番号
- US05444083
反応ノート
読み込み中…