N-Decyl-4-nitrobenzamide → 4-Amino-N-decylbenzamide

HRID 1757865ノート

反応式

HRID 1757865 の反応式
[CH2:1]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=1)=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]>[Pd].C1COCC1>[CH2:1]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

参加物

4

反応物 1

HCID 3414942N-Decyl-4-nitrobenzamide

生成物 1

HCID 193889594-Amino-N-decylbenzamide収率 95%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 8.05 g of 4-[(decylamino)carbonyl]nitrobenzene and 2.5 g of 10% palladium on carbon in 175 ml of THF was shaken under an initial hydrogen pressure of 54 psi in a Parr Hydrogenator for 17 hours. The catalyst was removed by filtration and the filtrate was concentrated to a solid which was triturated with hexane and filtered to give 6.88 g (95% yield, mp 117°-119°) of 4-[(decylamino)carbonyl]benzenamine.The structure was confirmed by the nmr spectrum.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated to a solid which
  3. customwas triturated with hexane
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-5f3ce0f9d8384ae9bcd638a2570fe5c2
出典データセット
uspto-grants-1995_08
特許番号
US05446189

反応ノート

読み込み中…