Hydrochloric Acid → 2-(4-Dimethylaminophenyl)benzofuran-7-carboxylic acid

HRID 1761911ノート

反応式

HRID 1761911 の反応式
[CH3:1][N:2]([CH3:22])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20]C)=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[CH:13]=2)=[CH:5][CH:4]=1.[OH-].[Na+].Cl>CO.O1CCCC1>[CH3:1][N:2]([CH3:22])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[CH:13]=2)=[CH:7][CH:8]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14229715Methyl 2-(4-dimethylaminophenyl)benzofuran-7-carboxylate

生成物 1

HCID 142297162-(4-Dimethylaminophenyl)benzofuran-7-carboxylic acid収率 99.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

920 mg of methyl 2-(4-dimethylaminophenyl)benzofuran-7-carboxylate are dissolved in a mixture of 20 ml of methanol and 20 ml of tetrahydrofuran. 10 ml of an aqueous 1N sodium hydroxide solution are added to the solution and the mixture is heated at 50° C. for 40 minutes. After cooling, the reaction mixture is neutralized with 10% hydrocloric acid and extracted with ethyl acetate. The extract is dried and evaporated to remove solvent to give 870 mg of 2-(4-dimethylaminophenyl)benzofuran-7-carboxylic acid as yellow powder.

後処理

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. customThe extract is dried
  4. customevaporated
  5. customto remove solvent

出典と根拠

ORDレコード
ord-89298c6253404621aebc81862be82b30
出典データセット
uspto-grants-1989_05
特許番号
US04829067

反応ノート

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