反応式
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([C:15](=[O:32])[CH2:16][N:17]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:18]([CH3:24])[CH2:19][C:20]([O:22]C)=[O:21])[CH:11]=[CH:10][C:9]=2[O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:5])C.CO.[OH-].[Na+].[ClH:45]>O1CCCC1>[ClH:45].[CH2:25]([N:17]([CH2:16][C:15]([C:12]1[CH:11]=[CH:10][C:9]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[C:8]2[C:13]=1[CH:14]=[C:6]([C:4]([OH:5])=[O:3])[NH:7]2)=[O:32])[CH:18]([CH3:24])[CH2:19][C:20]([OH:22])=[O:21])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
38 g of 4-[N-benzyl-N-(2-methoxycarbonyl-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid ethyl ester is stirred at room temperature for 4 hours in a mixture of 1 liter of tetrahydrofuran, 1 liter of methanol, and 350 ml of 2N sodium hydroxide solution. The reaction mixture is then acidified with 2N hydrochloric acid, concentrated until the onset of crystallization, cooled in an ice bath, and the resultant crystals are vacuum-filtered, thus producing 25.8 g of 4-[N-benzyl-N-(2-carboxy-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid hydrochloride, decomposing from 150° C. on.
後処理
- concentrationconcentrated until the onset of crystallization
- temperaturecooled in an ice bath
- filtrationthe resultant crystals are vacuum-filtered
出典と根拠
- ORDレコード
- ord-e40850b5379045e2b927b765461777c7
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04835175
関連ノート
読み込み中…