Hydrochloric Acid → HCID 70166468、化合物

HRID 1763724ノート

反応式

HRID 1763724 の反応式
[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH:8]C(OCC1C=CC=CC=1)=O.CO.[ClH:33].O>[Pd].O1CCCC1>[ClH:33].[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH2:8]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 13190522Z-Ser-Tyr-OMe

生成物 1

HCID 70166468HCID 70166468、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of 8.328 g. of Nα -benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [cf. Fischer and Whetstone, J. Am. Chem. Soc., 76, 5076 (1954)] and 500 mg. of 20% palladium on carbon is added 70 ml. of methanol containing 6.67 ml. of 3N hydrogen chloride in tetrahydrofuran and the mixture stirred under hydrogen at one inch water pressure for three hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated to dryness under reduced pressure to give a residue of L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

後処理

  1. additionTo a mixture of 8.328 g
  2. filtrationThe mixture is filtered
  3. customto remove the catalyst
  4. customthe filtrate is evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-b3d01121583d4361a7548b38655bd980
出典データセット
uspto-grants-1978_09
特許番号
US04111923

反応ノート

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