Hydrochloric Acid → L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

HRID 1763725ノート

反応式

HRID 1763725 の反応式
[CH3:1][O:2][C:3](=[O:44])[C@H:4]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=1)[NH:5][C:6](=[O:35])[C@H:7]([CH2:33][OH:34])[NH:8][C:9](=[O:32])[C@H:10]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH:11]C(OCC1C=CC=CC=1)=O.CO.[ClH:47]>[Pd].O1CCCC1>[ClH:47].[CH3:1][O:2][C:3](=[O:44])[C@H:4]([CH2:36][C:37]1[CH:38]=[CH:39][C:40]([OH:43])=[CH:41][CH:42]=1)[NH:5][C:6](=[O:35])[C@H:7]([CH2:33][OH:34])[NH:8][C:9](=[O:32])[C@H:10]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH2:11]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54186548HCID 54186548、化合物

生成物 1

HCID 70617527L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of 3.1 g. of Nα -benzyloxycarbonyl-L-trytophyl-L-seryl-L-tyrosine methyl ester and 200 mg. of 20% palladium on carbon is added 75 ml. of methanol containing 1.7 ml. of 3N hydrogen chloride in tetrahydrofuran and the reaction is stirred under an atmosphere of hydrogen for two and a half hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated under reduced pressure to give a residue of L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

後処理

  1. additionTo a mixture of 3.1 g
  2. filtrationThe mixture is filtered
  3. customto remove the catalyst
  4. customthe filtrate is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ff3903e65c1846ec828462fa69a4cdc2
出典データセット
uspto-grants-1978_09
特許番号
US04111923

反応ノート

読み込み中…