Methanol → O-Methyl-D-tyrosine methyl ester HCl

HRID 1763743ノート

反応式

HRID 1763743 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1.[CH3:16]O.S(Cl)([Cl:20])=O>N1C=CC=CC=1>[ClH:20].[CH3:16][O:12][C:11](=[O:13])[C@@H:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:15][CH:14]=1)[NH2:10]

参加物

5

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 51358314O-Methyl-D-tyrosine--hydrogen chloride (1/1)

生成物 1

HCID 24938358O-Methyl-D-tyrosine methyl ester HCl

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

O-Methyl-D-tyrosine hydrochloride, 10.0 g., in 100 ml. of methanol is cooled in an ice bath and treated slowly with 3.4 ml. of thionyl chloride. The reaction is stirred for one hour with cooling and then overnight at room temperature. The solution is evaporated to dryness and the residue crystallized from methanol-ether to give 5.2 g. of the above named compound mp. 189°-190° C., [α]D23 -68° (c 1.04, pyridine).

後処理

  1. additiontreated slowly with 3.4 ml
  2. temperaturewith cooling
  3. customovernight
  4. customat room temperature
  5. customThe solution is evaporated to dryness
  6. customthe residue crystallized from methanol-ether
  7. customto give 5.2 g

出典と根拠

ORDレコード
ord-28de2ce7fb2245979a99bb6c0a0a76e0
出典データセット
uspto-grants-1978_09
特許番号
US04111923

反応ノート

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