Iodine chloride → 5-Iodo-4-methyl-2-aminobenzenesulfonamide
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[C:4]([NH2:12])[CH:3]=1.[I:13]Cl>C(Cl)(Cl)Cl>[I:13][C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH2:12])=[C:5]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:6]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
A stirred suspension of 4-methyl-2-aminobenzenesulfonamide (620 mg; 3.3 mmol) in CHCl3 (7 ml) at 0° C. was added a solution of iodine monochloride (1.6 g; 9.9 mmol) in CHCl3 (7 ml). The reaction mixture was stirred at 0° C. until H-NMR indicated full conversion of starting material. The reaction mixture was filtered and the isolated solid washed with small volumes of CHCl3, NaHCO3 (sat. aq.), H2O and air dried to give 640 mg (62%) of product.
後処理
- filtrationThe reaction mixture was filtered
- washthe isolated solid washed with small volumes of CHCl3, NaHCO3 (sat. aq.), H2O and air
- customdried
出典と根拠
- ORDレコード
- ord-eaec7a9510814141b8cd7f26a8ff4623
- 出典データセット
- uspto-grants-2007_06
- 特許番号
- US07235548B2
反応ノート
読み込み中…