Hydrochloric Acid → N-[2-(5-methoxyindol-3-yl)ethyl]-N'-propylurea

HRID 1769160ノート

反応式

HRID 1769160 の反応式
[CH2:1]([N:4]=[C:5]=[O:6])[CH2:2][CH3:3].[CH3:7][O:8][C:9]1[CH:20]=[C:19]2[C:12]([NH:13][CH:14]=[C:15]2[CH2:16][CH2:17][NH2:18])=[CH:11][CH:10]=1.Cl>N1C=CC=CC=1>[CH3:7][O:8][C:9]1[CH:20]=[C:19]2[C:12](=[CH:11][CH:10]=1)[NH:13][CH:14]=[C:15]2[CH2:16][CH2:17][NH:18][C:5]([NH:4][CH2:1][CH2:2][CH3:3])=[O:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 18335-MethoxytryptamineHCID 61033Propyl isocyanate

生成物 1

HCID 10039072N-[2-(5-methoxyindol-3-yl)ethyl]-N'-propylurea収率 85%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

0.851 g of propyl isocyanate is added to a suspension of 1.902 g of 5-methoxytryptamine in 4 cm3 of pyridine at +5° C. The mixture is stirred at room temperature for 2 hours and then the reaction medium is poured onto ice-water. The mixture is acidified slightly with a 1N hydrochloric acid solution. The resulting precipitate is isolated by filtration, washed with water, dried and then recrystallised in toluene, yielding 2.34 g (85%) of N-[2-(5-methoxyindol-3-yl)ethyl]-N'-propylurea.

後処理

  1. additionthe reaction medium is poured onto ice-water
  2. customThe resulting precipitate is isolated by filtration
  3. washwashed with water
  4. customdried
  5. customrecrystallised in toluene

出典と根拠

ORDレコード
ord-39a90eb97dba40d284b82950acc2870a
出典データセット
uspto-grants-1995_01
特許番号
US05380750

反応ノート

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