1-Phenylpiperazine → alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

HRID 1769621

反応式

HRID 1769621 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([OH:23])(=[O:22])[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH2:15]>C(O)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:13]([OH:23])=[O:22])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 70961-PhenylpiperazineHCID 68114Atropic acid

生成物 1

HCID 19433570alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-Phenylpiperazine and atropic acid in ethanol is heated under reflux for 18 h, cooled to room temperature, and evaporated in vacuo. The solid is triturated with acetone to give the title product.

後処理

  1. temperatureunder reflux for 18 h
  2. customevaporated in vacuo
  3. customThe solid is triturated with acetone

出典と根拠

ORDレコード
ord-961838b3deaa45069abb4e91321a9fdd
出典データセット
uspto-grants-1995_01
特許番号
US05382583

関連ノート

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