Sulfuric Acid → 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene

HRID 1771650ノート

反応式

HRID 1771650 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[N+:9]([O-:11])=[O:10].OS(O)(=O)=O.C1C(=O)N([Br:24])C(=O)C1>C(O)(C(F)(F)F)=O>[Br:24][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([N+:9]([O-:11])=[O:10])[C:4]=1[CH3:8]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 67184N-bromobutanimideHCID 197738031-Fluoro-3-methyl-2-nitrobenzene

生成物 1

HCID 585404001-Bromo-4-fluoro-2-methyl-3-nitrobenzene収率 67%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

To a solution of 1-fluoro-3-methyl-2-nitro-benzene (5 g, 32.24 mmol, 1.0 eq) in TFA (25 mL) and conc.H2SO4 (10 mL) at 0° C. was added NBS (6.31 g, 35.46 mmol, 1.1 eq) in portions. After addition, the mixture was stirred at room temperature for 2 h. The resulting mixture was poured onto ice and the precipitate that formed collected by filtration, washed with water and dried in vacuo to give the title compound as a yellow solid (5 g, 67%).

後処理

  1. additionAfter addition
  2. additionThe resulting mixture was poured onto ice
  3. customthe precipitate that formed
  4. filtrationcollected by filtration
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-e59d487442eb4b0a99fbf1d3784c9198
出典データセット
uspto-grants-2016_02
特許番号
US09249085B2

反応ノート

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