Hydrochloric Acid → 5-Bromo-2-methoxy-3-methylbenzoic acid

HRID 1771694ノート

反応式

HRID 1771694 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH3:14])[C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+].O.Cl>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH3:14])[C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 2764346Methyl 5-bromo-2-methoxy-3-methylbenzoate

生成物 1

HCID 9619195-Bromo-2-methoxy-3-methylbenzoic acid収率 73.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 5-bromo-2-methoxy-3-methyl-benzoate (2.6 g, 10.0 mmol, 1.0 eq) in THF (20 mL) was added an aqueous solution of NaOH (2M, 20 mL, 40 mmol, 4.0 eq). The mixture was stirred at room temperature for 5 h. Water was added and the aqueous layer was acidified to pH 9 by addition of 1M HCl. The THF was removed in vacuo and the aqueous layer was further acidified to pH 4-5 with 1M HCl. The solid that precipitated from the reaction was collected by filtration and dried to give the title compound as a white solid (1.8 g, 73%).

後処理

  1. customThe THF was removed in vacuo
  2. customThe solid that precipitated from the reaction
  3. filtrationwas collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-c47194d446964f7cb9ee6b669610bc9f
出典データセット
uspto-grants-2016_02
特許番号
US09249085B2

反応ノート

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