Ammonia → HCID 81430592、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[C:5](O)=[O:6].O=S(Cl)Cl.[NH3:19]>C1COCC1>[Br:1][C:2]1[CH:10]=[C:9]([CH:8]=[C:4]([C:5](=[O:6])[NH2:19])[CH:3]=1)[C:11]([O:13][CH3:14])=[O:12]参加物
5
実験手順
To 3-bromo-5-methoxycarbonyl-benzoic acid (3 g, 11.6 mmol, 1 eq) was added SOCl2 (20 mL) and the reaction heated at reflux overnight. The excess SOCl2 was removed in vacuo and the residue obtained was dissolved in THF (15 mL) and added dropwise to a solution of NH3 (38% aqueous, 30 mL). The precipitate that formed was collected by filtration, washed with water and dried to give the title compound as a white solid (2.8 g, 94%).
後処理
- temperaturethe reaction heated
- temperatureat reflux overnight
- customThe excess SOCl2 was removed in vacuo
- customthe residue obtained
- customThe precipitate that formed
- filtrationwas collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-d8820c0f221b4cf49ec566a59d595dc0
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249085B2
反応ノート
読み込み中…