ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Pyridine → (2S)-2-amino-3-{[(5-chloro-2-hydroxy-3-sulfophenyl)carbamoyl]amino}propanoic acid

HRID 1773088
ノート
印刷プレビュー

反応式

HRID 1773088 の反応式
Cl.C([O:6][C:7](=[O:19])[C@H:8]([CH2:17][NH2:18])[NH:9]C(OC(C)(C)C)=O)(C)(C)C.[NH2:20][C:21]1[C:22]([OH:32])=[C:23]([S:28]([OH:31])(=[O:30])=[O:29])[CH:24]=[C:25]([Cl:27])[CH:26]=1.Cl[C:34](Cl)([O:36]C(=O)OC(Cl)(Cl)Cl)Cl.N1C=CC=CC=1>C(Cl)Cl>[NH2:9][C@@H:8]([CH2:17][NH:18][C:34](=[O:36])[NH:20][C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[C:23]([S:28]([OH:31])(=[O:30])=[O:29])[C:22]=1[OH:32])[C:7]([OH:6])=[O:19]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 1049PyridineHCID 69273-Amino-5-chloro-2-hydroxybenzenesulfonic acidHCID 94429TriphosgeneHCID 86679032(S)-tert-Butyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate hydrochloride

生成物 1

HCID 53377991(2S)-2-amino-3-{[(5-chloro-2-hydroxy-3-sulfophenyl)carbamoyl]amino}propanoic acid

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒

実験手順

297 mg (1 mmol) of 3-amino-N-(tert-butoxycarbonyl)-L-alanine tert-butylester hydrochloride, 223 mg (1 mmol) of 3-amino-5-chloro-2-hydroxybenzenesulfonic acid and 100 mg (0.33 mmol) of triphosgene were suspended in methylene chloride (3 ml), added with 0.8 ml of pyridine, and stirred at room temperature overnight. The solvent was distilled away, and the resultant residue was purified by employing purification step A to obtain the title compound in protected form. To the resulting protected form, 3 ml of trifluoroacetic acid was added, and the resultant was stirred for 5 hours. Subsequently, the solvent was distilled away and the obtained residue was purified using purification step A to obtain the title compound.

後処理

  1. distillationThe solvent was distilled away
  2. customthe resultant residue was purified
  3. custompurification step A

出典と根拠

ORDレコード
ord-6da356e5e2dd435193d4a9503209f595
出典データセット
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09253997B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート