N-bromobutanimide → Ethyl 2-(4-amino-3-bromophenyl)acetate

HRID 1773973

反応式

HRID 1773973 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.[Br:14]N1C(=O)CCC1=O>CC#N>[CH2:12]([O:11][C:9](=[O:10])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([NH2:1])=[C:7]([Br:14])[CH:6]=1)[CH3:13]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 225219p-Aminophenylacetic acid ethyl ester

生成物 1

HCID 19702145Ethyl 2-(4-amino-3-bromophenyl)acetate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of ethyl 4-aminophenylacetate (1.79 g, 10 mmol, 1 eq.) in MeCN (50 mL), N-bromsuccinimide (1.78 g, 10 mmol, 1 eq.) was added slowly. The mixture was stirred at r.t. for 72 hours. The reaction mixture was concentrated in vacuo. The residue was partitioned between water (50 mL) and Et2O (50 mL). The org. phase was washed with sat. aq. NaCl soln. (1×50 mL), dried over MgSO4, and concentrated in vacuo to give (4-amino-3-bromo-phenyl)-acetic acid ethyl ester as an orange oil. The product was used without further purification.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe residue was partitioned between water (50 mL) and Et2O (50 mL)
  3. washphase was washed with sat. aq. NaCl soln
  4. dry with material(1×50 mL), dried over MgSO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e986737d4dab4274bb71e2f7d4a0cac2
出典データセット
uspto-grants-2016_02
特許番号
US09255090B2

関連ノート

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