Dibenzyl 2-isopropyl-2-hydroxy-3-methylsuccinate → 2-Hydroxy-2-isopropyl-3-methylsuccinic acid
反応式
[CH:1]([C:4]([OH:27])([CH:15]([CH3:26])[C:16]([O:18]CC1C=CC=CC=1)=[O:17])[C:5]([O:7]CC1C=CC=CC=1)=[O:6])([CH3:3])[CH3:2]>O1CCCC1.[Pd]>[OH:27][C:4]([CH:1]([CH3:3])[CH3:2])([CH:15]([CH3:26])[C:16]([OH:18])=[O:17])[C:5]([OH:7])=[O:6]参加物
4
実験手順
The dibenzyl 2-isopropyl-2-hydroxy-3-methylsuccinate thus obtained was dissolved in tetrahydrofuran (25 mL), and the solution was stirred in the presence of 10% palladium/carbon (120 mg) under hydrogen stream at room temperature for 15 h. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give 748 mg of 2-hydroxy-2-isopropyl-3-methylsuccinic acid as oil (quantitative).
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e691a0c0dbfe4fa983fdb084ce3fcd17
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260375B2
反応ノート
読み込み中…