Dimethylformamide → HCID 71626459、化合物

反応式

[CH3:1][C:2]1([CH3:19])[CH2:14][C:13]2=[N:15][NH:16][C:17](=[O:18])[C:10]3[C:11]4[C:12]2=C(NC=4[CH:7]=[CH:8][CH:9]=3)[CH2:3]1.[H-].[Na+].[CH3:22]I.[CH3:24][N:25]([CH:27]=O)[CH3:26]>>[CH3:1][C:2]1([CH3:19])[CH2:14][C:13]2=[N:15][N:16]([CH3:22])[C:17](=[O:18])[C:10]3[C:11]4[C:12]2=[C:27]([N:25]([CH3:24])[C:26]=4[CH:7]=[CH:8][CH:9]=3)[CH2:3]1

参加物

反応物 4

HCID 6228Dimethylformamide

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 136242904HCID 136242904、化合物

生成物 1

HCID 71626459HCID 71626459、化合物収率 95%

実験手順

The desired product was prepared using a procedure similar to step 1 of Example 22. Subsequently, 2,2-dimethyl-2,3,5,10-tetrahydro-[1,2]diazepino[3,4,5,6-def]carbazol-6(1H)-one (0.02 g, 0.08 mmol) was reacted with NaH (2.4 mg, 0.1 mmol) and methyl iodide (0.06 g, 0.4 mmol) in DMF (2 ml) to give the desired product (20 mg, 95%) as yellow solid. 1H NMR (DMSO-d6) δ 7.51-7.55 (m, 2H), 7.16 (t, 1H, J=7.8 Hz), 3.69 (s, 3H), 3.42 (s, 3H), 2.72 (s, 2H), 2.27 (s, 2H), and 1.09 (s, 6H). MS (ESI) m/e [M+1]+ 282.