HCID 86679502、化合物 → HCID 86679503、化合物

HRID 1776547ノート

反応式

HRID 1776547 の反応式
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])=[CH:5][C:4]=1[N:19]([CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[S:20]([CH3:23])(=[O:22])=[O:21]>CO.C(Cl)(Cl)Cl.[Pd]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[N:19]([CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)[S:20]([CH3:23])(=[O:22])=[O:21]

参加物

5

反応物 1

HCID 86679502HCID 86679502、化合物

生成物 1

HCID 86679503HCID 86679503、化合物収率 58.5%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回HCID 6212Chloroform溶媒

実験手順

Benzyl 4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoate (1.5 g, 3.34 mmol) was dissolved in MeOH (20 ml), then Pd/C 5% (0.33 mmol, 702 mg) was added, and the mixture was hydrogenated in a Parr apparatus (H2:35 psi) for 30 minutes. The reaction was diluted with CHCl3 (300 ml) and MeOH (300 ml) to dissolve the product that precipitated in MeOH, and the catalyst was filtered over a celite pad, and the solvent is evaporated under vacuum, to yield 700 mg of white solid.

後処理

  1. dissolutionto dissolve the product that
  2. customprecipitated in MeOH
  3. filtrationthe catalyst was filtered over a celite pad
  4. customthe solvent is evaporated under vacuum

出典と根拠

ORDレコード
ord-1805dc38ee514846a54527a777e199ab
出典データセット
uspto-grants-2016_02
特許番号
US09265768B2

反応ノート

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