Sodium Hydroxide → 4-Chloro-2-(1H-pyrazol-3-yl)phenol
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6](/[CH:8]=[C:9](\C)/[CH:10]=O)[CH:7]=1.CC1C=CC(S([NH:24][NH2:25])(=O)=O)=CC=1.[OH-].[Na+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]([C:8]2[CH:9]=[CH:10][NH:25][N:24]=2)[CH:7]=1参加物
5
実験手順
A mixture of (E)-3-(5-chloro-2-hydroxyphenyl)-2-methylacrylaldehyde (40 mg, 0.203 mmol) and 4-methylbenzenesulfonohydrazide (41.7 mg, 0.224 mmol) in Acetonitrile (3 mL) were stirred at room temperature for 3 h and then acetonitrile (2 mL), Sodiumhydroxide (8.95 mg, 0.224 mmol) were added and the mixture was heated at reflux for 16 h. Product was used for further reaction without purification.
後処理
- temperaturethe mixture was heated
- temperatureat reflux for 16 h
- customProduct was used for further reaction without purification
出典と根拠
- ORDレコード
- ord-e93c3bc0b808426aa4568fbd3d4bdadd
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266838B2
反応ノート
読み込み中…