P-Cresol → Ethyl (p-tolyloxy)acetate

HRID 1777099

反応式

HRID 1777099 の反応式
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>CC#N>[C:3]1([CH3:8])[CH:4]=[CH:5][C:6]([O:7][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:1][CH:2]=1

参加物

5

反応物 3

HCID 2879P-CresolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

生成物 1

HCID 4047281Ethyl (p-tolyloxy)acetate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

To a mixture of p-cresol (500 mg, 4.63 mmol) and ethyl 2-bromoacetate (928 mg, 5.56 mmol) in CH3CN (10 mL) was added K2CO3 (3 g, 21.7 mmol). The reaction mixture was stirred at 80° C. for 4 h. The solid was removed by filtration and the filtrate was concentrated to give the title compound which was used in the next step without further purification.

後処理

  1. customThe solid was removed by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-ae7cc55cd61e4573944615b91447b282
出典データセット
uspto-grants-2016_02
特許番号
US09266836B2

関連ノート

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